diff --git a/build/cmake/setup.cmake b/build/cmake/setup.cmake
index 297a251f28..b352e61c95 100644
--- a/build/cmake/setup.cmake
+++ b/build/cmake/setup.cmake
@@ -613,6 +613,13 @@ check_type_size(ssize_t SSIZE_T)
 
 test_big_endian(WORDS_BIGENDIAN)
 
+if(wxUSE_WEBVIEW_CHROMIUM)
+    string(TOUPPER ${CMAKE_BUILD_TYPE} build_type)
+    if(${build_type} STREQUAL DEBUG)
+        set(wxHAVE_CEF_DEBUG ON)
+    endif()
+endif()
+
 configure_file(build/cmake/setup.h.in ${wxSETUP_HEADER_FILE})
 if(DEFINED wxSETUP_HEADER_FILE_DEBUG)
     # The debug version may be configured with different values in the future
diff --git a/build/cmake/setup.h.in b/build/cmake/setup.h.in
index da17cf6fd4..666e3d46e0 100644
--- a/build/cmake/setup.h.in
+++ b/build/cmake/setup.h.in
@@ -598,6 +598,11 @@
 #cmakedefine01 wxUSE_SELECT_DISPATCHER
 #cmakedefine01 wxUSE_EPOLL_DISPATCHER
 
+/*
+   Use debug version of CEF in wxWebViewChromium.
+ */
+#cmakedefine wxHAVE_CEF_DEBUG
+
 /*
    Use GStreamer for Unix.