diff --git a/build/cmake/setup.h.in b/build/cmake/setup.h.in
index 36e09fc4e2..dd44a0b70d 100644
--- a/build/cmake/setup.h.in
+++ b/build/cmake/setup.h.in
@@ -747,12 +747,6 @@
  */
 #cmakedefine VA_LIST_IS_ARRAY 1
 
-/*
- * Define if you don't want variadic macros to be used even if they are
- * supported by the compiler.
- */
-#cmakedefine wxNO_VARIADIC_MACROS
-
 /*
  * Define if your compiler has std::wstring
  */
diff --git a/configure b/configure
index c70d8208f4..2767e097c3 100755
--- a/configure
+++ b/configure
@@ -24278,11 +24278,6 @@ $as_echo "$wx_cv_type_va_list_lvalue" >&6; }
     fi
 fi
 
-if test "$wxUSE_VARARG_MACROS" != "yes"; then
-    $as_echo "#define wxNO_VARIADIC_MACROS 1" >>confdefs.h
-
-fi
-
 LARGEFILE_CPPFLAGS=
 # Check whether --enable-largefile was given.
 if test "${enable_largefile+set}" = set; then :
diff --git a/configure.in b/configure.in
index 4b8dc950e4..008cad8d3a 100644
--- a/configure.in
+++ b/configure.in
@@ -1717,15 +1717,6 @@ else
     fi
 fi
 
-dnl TODO-C++11: remove this, as it won't make sense when C++11 is required
-dnl don't use vararg macros if they're explicitly disabled: this is
-dnl useful if the user code using the library wants to limit itself to standard
-dnl C++ only (e.g. is compiled with g++ -std=c++98)
-if test "$wxUSE_VARARG_MACROS" != "yes"; then
-    AC_DEFINE(wxNO_VARIADIC_MACROS)
-fi dnl wxUSE_VARARG_MACROS == yes
-
-
 dnl check for large file support
 LARGEFILE_CPPFLAGS=
 AC_SYS_LARGEFILE
diff --git a/include/wx/cpp.h b/include/wx/cpp.h
index 2f2b277647..d6873e5b30 100644
--- a/include/wx/cpp.h
+++ b/include/wx/cpp.h
@@ -123,23 +123,6 @@
 #endif /* __WXFUNCTION__ already defined */
 
 
-/* Auto-detect variadic macros support unless explicitly disabled. */
-#if !defined(HAVE_VARIADIC_MACROS) && !defined(wxNO_VARIADIC_MACROS)
-    /* Any C99 or C++11 compiler should have them. */
-    #if (defined(__STDC_VERSION__) && __STDC_VERSION__ >= 199901L) || \
-        (defined(__cplusplus) && __cplusplus >= 201103L)
-        #define HAVE_VARIADIC_MACROS 1
-    #elif defined(__GNUC__)
-        #define HAVE_VARIADIC_MACROS 1
-    #elif wxCHECK_VISUALC_VERSION(8)
-        #define HAVE_VARIADIC_MACROS 1
-    #endif
-#endif /* !HAVE_VARIADIC_MACROS */
-
-
-
-#ifdef HAVE_VARIADIC_MACROS
-
 /*
    wxCALL_FOR_EACH(what, ...) calls the macro from its first argument, what(pos, x),
    for every remaining argument 'x', with 'pos' being its 1-based index in
@@ -185,9 +168,5 @@
 #define wxCALL_FOR_EACH(what, ...) \
     wxCALL_FOR_EACH_(wxCALL_FOR_EACH_NARG(__VA_ARGS__), (what, __VA_ARGS__))
 
-#else
-    #define wxCALL_FOR_EACH  Error_wx_CALL_FOR_EACH_requires_variadic_macros_support
-#endif /* HAVE_VARIADIC_MACROS */
-
 #endif /* _WX_CPP_H_ */
 
diff --git a/include/wx/log.h b/include/wx/log.h
index 9ab02d6c5e..60e7a73cdc 100644
--- a/include/wx/log.h
+++ b/include/wx/log.h
@@ -1336,12 +1336,7 @@ inline void wxLogNop() { }
     #define wxVLogDebug(format, argptr) wxDO_LOGV(Debug, format, argptr)
 #else // !wxUSE_LOG_DEBUG
     #define wxVLogDebug(fmt, valist) wxLogNop()
-
-    #ifdef HAVE_VARIADIC_MACROS
-        #define wxLogDebug(fmt, ...) wxLogNop()
-    #else // !HAVE_VARIADIC_MACROS
-        WX_DEFINE_VARARG_FUNC_NOP(wxLogDebug, 1, (const wxFormatString&))
-    #endif
+    #define wxLogDebug(fmt, ...) wxLogNop()
 #endif // wxUSE_LOG_DEBUG/!wxUSE_LOG_DEBUG
 
 #if wxUSE_LOG_TRACE
@@ -1349,12 +1344,7 @@ inline void wxLogNop() { }
     #define wxVLogTrace wxDO_LOG_IF_ENABLED_WITH_FUNC(Trace, LogVTrace)
 #else  // !wxUSE_LOG_TRACE
     #define wxVLogTrace(mask, fmt, valist) wxLogNop()
-
-    #ifdef HAVE_VARIADIC_MACROS
-        #define wxLogTrace(mask, fmt, ...) wxLogNop()
-    #else // !HAVE_VARIADIC_MACROS
-        WX_DEFINE_VARARG_FUNC_NOP(wxLogTrace, 2, (const wxString&, const wxFormatString&))
-    #endif // HAVE_VARIADIC_MACROS/!HAVE_VARIADIC_MACROS
+    #define wxLogTrace(mask, fmt, ...) wxLogNop()
 #endif // wxUSE_LOG_TRACE/!wxUSE_LOG_TRACE
 
 // wxLogFatalError helper: show the (fatal) error to the user in a safe way,
diff --git a/include/wx/testing.h b/include/wx/testing.h
index 44417af949..7cbcb8bbda 100644
--- a/include/wx/testing.h
+++ b/include/wx/testing.h
@@ -515,8 +515,6 @@ private:
           wxExpectModal<> for your dialog type and implement its OnInvoked()
           method.
  */
-#ifdef HAVE_VARIADIC_MACROS
-
 #define wxTEST_DIALOG(codeToRun, ...)                                          \
     {                                                                          \
         wxTEST_DIALOG_HOOK_CLASS wx_hook(__FILE__, __LINE__, __WXFUNCTION__);  \
@@ -524,7 +522,6 @@ private:
         codeToRun;                                                             \
         wx_hook.CheckUnmetExpectations();                                      \
     }
-#endif /* HAVE_VARIADIC_MACROS */
 
 #endif // !WXBUILDING
 
diff --git a/setup.h.in b/setup.h.in
index 7cbe89b7ee..365c3c7d3b 100644
--- a/setup.h.in
+++ b/setup.h.in
@@ -747,12 +747,6 @@
  */
 #undef VA_LIST_IS_ARRAY
 
-/*
- * Define if you don't want variadic macros to be used even if they are
- * supported by the compiler.
- */
-#undef wxNO_VARIADIC_MACROS
-
 /*
  * Define if your compiler has std::wstring
  */
diff --git a/src/common/markupparser.cpp b/src/common/markupparser.cpp
index 257d106421..4c5f6042d8 100644
--- a/src/common/markupparser.cpp
+++ b/src/common/markupparser.cpp
@@ -279,7 +279,7 @@ bool wxMarkupParser::Parse(const wxString& text)
                     // and doesn't need to be defined if they're not compiled
                     // at all (it actually would result in unused variable
                     // messages in this case).
-#if wxUSE_LOG_DEBUG || !defined(HAVE_VARIADIC_MACROS)
+#if wxUSE_LOG_DEBUG
                     // Remember the tag starting position for the error
                     // messages.
                     const size_t pos = it - text.begin();
diff --git a/tests/controls/dialogtest.cpp b/tests/controls/dialogtest.cpp
index 75e85c02cc..cdd04b6489 100644
--- a/tests/controls/dialogtest.cpp
+++ b/tests/controls/dialogtest.cpp
@@ -11,8 +11,6 @@
 
 #include "wx/testing.h"
 
-#ifdef HAVE_VARIADIC_MACROS
-
 #include "wx/msgdlg.h"
 #include "wx/filedlg.h"
 
@@ -172,5 +170,3 @@ void ModalDialogsTestCase::InitDialog()
     dlg.ShowModal();
     CPPUNIT_ASSERT( dlg.WasModal() );
 }
-
-#endif // HAVE_VARIADIC_MACROS
diff --git a/tests/misc/misctests.cpp b/tests/misc/misctests.cpp
index ddd7063a69..3571514aa0 100644
--- a/tests/misc/misctests.cpp
+++ b/tests/misc/misctests.cpp
@@ -39,9 +39,7 @@ public:
 private:
     CPPUNIT_TEST_SUITE( MiscTestCase );
         CPPUNIT_TEST( Assert );
-#ifdef HAVE_VARIADIC_MACROS
         CPPUNIT_TEST( CallForEach );
-#endif // HAVE_VARIADIC_MACROS
         CPPUNIT_TEST( Delete );
         CPPUNIT_TEST( StaticCast );
     CPPUNIT_TEST_SUITE_END();
@@ -83,7 +81,6 @@ void MiscTestCase::Assert()
     wxSetAssertHandler(oldHandler);
 }
 
-#ifdef HAVE_VARIADIC_MACROS
 void MiscTestCase::CallForEach()
 {
     #define MY_MACRO(pos, str) s += str;
@@ -95,7 +92,6 @@ void MiscTestCase::CallForEach()
 
     #undef MY_MACRO
 }
-#endif // HAVE_VARIADIC_MACROS
 
 void MiscTestCase::Delete()
 {