diff --git a/build/cmake/config.cmake b/build/cmake/config.cmake
index 02d2ba0a35..b68d167dac 100644
--- a/build/cmake/config.cmake
+++ b/build/cmake/config.cmake
@@ -177,6 +177,9 @@ function(wx_write_config)
     foreach(flag IN LISTS wxTOOLKIT_DEFINITIONS)
         wx_string_append(WXCONFIG_CPPFLAGS " -D${flag}")
     endforeach()
+    if(wxBUILD_LARGEFILE_SUPPORT)
+        wx_string_append(WXCONFIG_CPPFLAGS " -D_FILE_OFFSET_BITS=64")
+    endif()
     string(STRIP "${WXCONFIG_CPPFLAGS}" WXCONFIG_CPPFLAGS)
     set(WXCONFIG_CXXFLAGS ${WXCONFIG_CFLAGS})
     set(WXCONFIG_LDFLAGS_GUI)
diff --git a/build/cmake/functions.cmake b/build/cmake/functions.cmake
index 8d43c56268..f927c9be7a 100644
--- a/build/cmake/functions.cmake
+++ b/build/cmake/functions.cmake
@@ -160,6 +160,19 @@ function(wx_set_common_target_properties target_name)
         )
     endif()
 
+    if(wxUSE_NO_RTTI)
+        if(MSVC)
+            target_compile_options(${target_name} PRIVATE "/GR-")
+        elseif(("${CMAKE_CXX_COMPILER_ID}" STREQUAL "GNU") OR ("${CMAKE_CXX_COMPILER_ID}" MATCHES "Clang"))
+            target_compile_options(${target_name} PRIVATE "-fno-rtti")
+        endif()
+        target_compile_definitions(${target_name} PRIVATE "-DwxNO_RTTI")
+    endif()
+
+    if(wxBUILD_LARGEFILE_SUPPORT)
+        target_compile_definitions(${target_name} PUBLIC "-D_FILE_OFFSET_BITS=64")
+    endif()
+
     if(CMAKE_USE_PTHREADS_INIT)
         target_compile_options(${target_name} PRIVATE "-pthread")
         # clang++.exe: warning: argument unused during compilation: '-pthread' [-Wunused-command-line-argument]
diff --git a/build/cmake/init.cmake b/build/cmake/init.cmake
index d1f035953f..796867d23d 100644
--- a/build/cmake/init.cmake
+++ b/build/cmake/init.cmake
@@ -101,15 +101,6 @@ if(NOT wxBUILD_COMPATIBILITY STREQUAL "NONE")
     endif()
 endif()
 
-if(wxUSE_NO_RTTI)
-    if(MSVC)
-        add_compile_options("/GR-")
-    elseif(("${CMAKE_CXX_COMPILER_ID}" STREQUAL "GNU") OR ("${CMAKE_CXX_COMPILER_ID}" MATCHES "Clang"))
-        wx_string_append(CMAKE_CXX_FLAGS " -fno-rtti")
-    endif()
-    add_definitions("-DwxNO_RTTI")
-endif()
-
 # Build wxBUILD_FILE_ID used for config and setup path
 #TODO: build different id for WIN32
 set(wxBUILD_FILE_ID "${wxBUILD_TOOLKIT}${wxBUILD_WIDGETSET}-")
@@ -341,6 +332,10 @@ if(UNIX)
             wx_option_force_value(wxUSE_LIBICONV OFF)
         endif()
     endif()
+
+    if(wxBUILD_LARGEFILE_SUPPORT)
+        set(HAVE_LARGEFILE_SUPPORT ON)
+    endif()
 endif(UNIX)
 
 if(wxUSE_GUI)
diff --git a/build/cmake/options.cmake b/build/cmake/options.cmake
index 2c70d91763..96f3c504c4 100644
--- a/build/cmake/options.cmake
+++ b/build/cmake/options.cmake
@@ -56,6 +56,11 @@ if(NOT MSVC OR MSVC_VERSION GREATER 1800)
               ${wxCXX_STANDARD_DEFAULT} STRINGS COMPILER_DEFAULT 11 14 17 20)
 endif()
 
+if(UNIX)
+    wx_option(wxBUILD_LARGEFILE_SUPPORT "support for large files")
+    mark_as_advanced(wxBUILD_LARGEFILE_SUPPORT)
+endif()
+
 if(WIN32)
     set(wxBUILD_VENDOR "custom" CACHE STRING "Short string identifying your company (used in DLL name)")
 endif()
diff --git a/build/cmake/setup.cmake b/build/cmake/setup.cmake
index 8e3ec91d94..75d7f0c341 100644
--- a/build/cmake/setup.cmake
+++ b/build/cmake/setup.cmake
@@ -45,6 +45,7 @@ endif()
 if(UNIX)
     wx_setup_definition(wxUSE_UNIX)
     wx_setup_definition(__UNIX__)
+    list(APPEND CMAKE_REQUIRED_DEFINITIONS -D_FILE_OFFSET_BITS=64)
 endif()
 
 if(UNIX AND NOT APPLE)
@@ -346,6 +347,10 @@ if(UNIX)
 
     wx_check_funcs(fdopen)
 
+    if(wxBUILD_LARGEFILE_SUPPORT)
+        wx_check_funcs(fseeko)
+    endif()
+
     if(wxUSE_TARSTREAM)
         wx_check_funcs(sysconf)
 
diff --git a/docs/doxygen/overviews/cmake.md b/docs/doxygen/overviews/cmake.md
index b7427433f9..dc887fd059 100644
--- a/docs/doxygen/overviews/cmake.md
+++ b/docs/doxygen/overviews/cmake.md
@@ -114,7 +114,9 @@ Your *CMakeLists.txt* would look like this:
 ...
 
 find_package(wxWidgets REQUIRED COMPONENTS net core base)
-include(${wxWidgets_USE_FILE})
+if(wxWidgets_USE_FILE) # not defined in CONFIG mode
+    include(${wxWidgets_USE_FILE})
+endif()
 add_executable(myapp myapp.cpp)
 target_link_libraries(myapp ${wxWidgets_LIBRARIES})
 ~~~